Indication Tooltip

LORBRENA® (lorlatinib) is a prescription medicine that is used to treat people with non-small cell lung cancer (NSCLC)

  • that is caused by an abnormal anaplastic lymphoma kinase (ALK) gene, and
  • that has spread to other parts of the body, and
  • who have taken the medicine:
    • alectinib, or ceritinib, or
    • both crizotinib and at least 1 other medicine to treat NSCLC that is caused by the ALK gene, and
  • that is no longer responding to these treatments.

It is not known if LORBRENA is safe and effective in children.

The effectiveness of LORBRENA is based on a study that measured tumor response rate and duration of response. There is an ongoing study to find out how LORBRENA works over a longer period of time.

It's important to feel confident in your treatment decisions. If you are considering taking LORBRENA®, you may want to ask your doctor the following questions:

  1. Has LORBRENA been shown to be effective in patients with a treatment history similar to mine?
  2. How will I know LORBRENA is working?
  3. What are the potential side effects that I may experience while taking LORBRENA?
  4. How can I best communicate with you if I experience side effects?
  5. Will I have to make any lifestyle changes if I am prescribed LORBRENA?

To help you remember what was discussed, try bringing a notepad and pen to your appointments so you can write down what you hear.

Tell your healthcare provider about the medicines you take, including prescription medicines, over-the-counter medicines, vitamins, and herbal supplements.

How to Take LORBRENA

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Take LORBRENA exactly as your healthcare provider tells you to take it. Do not change your dose or stop taking LORBRENA unless your healthcare provider tells you to do so.

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Your healthcare provider may change your dose, temporarily stop, or permanently stop treatment with LORBRENA if you develop side effects.

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Swallow LORBRENA tablets whole. Do not chew, crush, or split LORBRENA tablets. Do not take LORBRENA tablets if they are broken, cracked, or not intact.

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Take LORBRENA at approximately the same time each day.

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You may take LORBRENA with or without food.

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If you miss a dose, take it as soon as you remember. However, if it is close to the time of your next dose (within 4 hours), just take your next dose at your regular time.

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If you vomit after taking a dose of LORBRENA, do not take an extra dose. Take your next dose at your regular time.


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