Indication Tooltip

LORBRENA® (lorlatinib) is a prescription medicine that is used to treat people with non-small cell lung cancer (NSCLC)

  • that is caused by an abnormal anaplastic lymphoma kinase (ALK) gene, and
  • that has spread to other parts of the body, and
  • who have taken the medicine:
    • alectinib, or ceritinib, or
    • both crizotinib and at least 1 other medicine to treat NSCLC that is caused by the ALK gene, and
  • that is no longer responding to these treatments.

It is not known if LORBRENA is safe and effective in children.

The effectiveness of LORBRENA is based on a study that measured tumor response rate and duration of response. There is an ongoing study to find out how LORBRENA works over a longer period of time.

Over Time, LORBRENA Was Shown to Treat ALK+ NSCLC Tumors That Had Spread to Other Parts of the Body

The length of time these partial and complete responses lasted before the tumors resumed growing or spreading was a median time period Median time period: In a cancer treatment study, it often means that half of the patients responded to a treatment for at least a specific amount of time, and half responded for less than that specific amount of time. of 12.5 months.Median time period: In a cancer treatment study, it often means that half of the patients responded to a treatment for at least a specific amount of time, and half responded for less than that specific amount of time.

For patients who began the study with NSCLC tumors that had spread to the brain, the length of time these partial and complete brain responses lasted before the tumors resumed growing or spreading was a median time period Median time period: In a cancer treatment study, it often means that half of the patients responded to a treatment for at least a specific amount of time, and half responded for less than that specific amount of time. of 19.5 months.Median time period: In a cancer treatment study, it often means that half of the patients responded to a treatment for at least a specific amount of time, and half responded for less than that specific amount of time.

ALK=anaplastic lymphoma kinase; NSCLC=non-small cell lung cancer.

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