Indication Tooltip

LORBRENA® (lorlatinib) is a prescription medicine that is used to treat people with non-small cell lung cancer (NSCLC)

  • that is caused by an abnormal anaplastic lymphoma kinase (ALK) gene, and
  • that has spread to other parts of the body, and
  • who have taken the medicine:
    • alectinib, or ceritinib, or
    • both crizotinib and at least 1 other medicine to treat NSCLC that is caused by the ALK gene, and
  • that is no longer responding to these treatments.

It is not known if LORBRENA is safe and effective in children.

The effectiveness of LORBRENA is based on a study that measured tumor response rate and duration of response. There is an ongoing study to find out how LORBRENA works over a longer period of time.

Recognizing Changes

LORBRENA may cause some side effects that you did not experience while on other ALK inhibitor medicines. These side effects include increased cholesterol and/or triglycerides, hallucinations, seizures, and changes in mood, memory, thinking, or speech.

If you experience side effects, know that with your doctor's guidance, there may be ways to help manage them.

It may be helpful to have an open conversation with your family or caregiver about the potential side effects of LORBRENA. They may be able to help you recognize any changes and can help you share them with your doctor.

Turn to Pfizer Oncology Together™ to learn about financial assistance resources and get personalized support from one of our dedicated Care Champions.