A new diagnosis can bring up a lot of questions and emotions. You don’t have to face it alone. LORBRENA offers tools and resources to help you and your loved ones feel informed, supported, and ready for what’s ahead.

Financial assistance

If needed, we'll help you find potential financial assistance options for your prescribed Pfizer Oncology medicine, regardless of your insurance coverage. This applies to patients who are eligible and cannot afford to pay for their medicine.

Commercially insured

Resources for eligible patients with commercial, private, employer, or state health insurance marketplace coverage:

Eligible, commercially insured patients may pay as little as $0 per month for their Pfizer Oncology treatment. Limits, terms, and conditions apply.* Patients may receive up to $10,600 per product in savings annually.

Sign up

*Patients are not eligible to use this card if they are enrolled in a state or federally funded insurance program, including but not limited to Medicare, Medicaid, TRICARE, Veterans Affairs health care, a state prescription drug assistance program, or the Government Health Insurance Plan available in Puerto Rico.

Medicare/government insured

Help identifying resources for eligible patients with Medicare/Medicare Part D, Medicaid, or other government insurance plans who express a financial need:

We can assist patients with searching for financial support from alternate funding resources, which may include financial assistance through Extra Help, a Medicare Part D Low-Income Subsidy (LIS) program.

If support from alternate funding resources or Medicare Extra Help is not available, Pfizer Oncology Together will see if patients are eligible for the Pfizer Patient Assistance Program, † which can provide prescribed Pfizer Oncology medicines for free.

†The Pfizer Patient Assistance Program is a joint program of Pfizer Inc. and the Pfizer Patient Assistance Foundation™. Free medicines from Pfizer are provided through the Pfizer Patient Assistance Foundation™. The Pfizer Patient Assistance Foundation™ is a separate legal entity from Pfizer Inc. with distinct legal restrictions.

Uninsured

Help identifying resources for eligible patients without any form of healthcare coverage:

We can check patient eligibility for Medicaid and help them understand how to apply.

If patients do not qualify for Medicaid, they may receive their medicine for free for up to 1 year through the Pfizer Patient Assistance Program. ‡ Patients must be eligible and reapply as needed.

‡The Pfizer Patient Assistance Program is a joint program of Pfizer Inc. and the Pfizer Patient Assistance Foundation™. Free medicines from Pfizer are provided through the Pfizer Patient Assistance Foundation™. The Pfizer Patient Assistance Foundation™ is a separate legal entity from Pfizer Inc. with distinct legal restrictions.

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Turn to Pfizer Oncology Together for financial assistance resources and personalized support.

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Call 1-877-744-5675
(Monday–Friday 8 am–8 pm ET)

Visit PfizerOncologyTogether.com

Receive support by signing up for LORBRENA Together

LORBRENA Together is a program meant to help you navigate your treatment journey. It offers information and resources to help answer questions or concerns you may have about ALK+ mNSCLC and LORBRENA. Sign up to get access to:

  • Real patient stories, where people discuss topics like diagnosis, treatment experience, and more
  • Information about financial assistance and insurance benefits
  • Support, tips, tools, and other helpful resources throughout your treatment

Please complete the errors below in red to register.

LORBRENA Together

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Privacy statement

By clicking “Sign up,” you agree to share your contact information and certain health information with Pfizer and Pfizer’s service providers and grant permission for those entities to send you helpful information regarding Pfizer’s products, treatments, and offers. Pfizer values your privacy; this personal information will be handled in accordance with our Privacy Policy. You can unsubscribe from these communications at any time by clicking “Unsubscribe” in the communications you receive.

Downloadable resources

Advocacy and education

Below are a few of the many organizations that provide helpful resources, like connection to support communities and information on the latest lung cancer research. For information about support groups near you, check with your hospital or care team.

ALK Positive Inc. is a patient-driven organization that seeks a cure for ALK-positive cancer and works to improve patients' quality of life and life expectancy worldwide.

Visit

The American Cancer Society funds and conducts research, shares expert information, and provides support for patients and their loved ones who have been affected by cancer.

Visit

GO2 for Lung Cancer is dedicated to increasing survival for those at risk, diagnosed, and living with lung cancer. They are the go-to for one-on-one assistance, supportive connections, treatment information, and finding the best care close to home.

Visit

Lung Cancer Foundation of America works to change the public perception of lung cancer through education and personal stories and to improve patient outcomes by funding research.

Visit

The Lung Cancer Research Foundation funds research for the prevention, diagnosis, treatment, and cure for lung cancer, providing awareness and educational programs supporting the lung cancer community.

Visit

LUNGevity Foundation seeks to make an immediate impact on quality of life and survivorship for everyone touched by the disease through research, community, and advocacy.

Visit

Third-party websites are not owned or controlled by Pfizer. Pfizer does not endorse and is not responsible for the content or services of these sites.

For care partners

When someone you love is diagnosed with cancer, your support can make a real difference. These tips and resources can help you feel more prepared and connected as you move forward together.

Be your loved one's eyes and ears

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If you are going to your loved one's appointments with them, it is helpful to take notes, ask questions, and meet the doctor and healthcare team. The Conversation Guide may help you prepare.

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Your loved one will receive a lot of information. Have a folder or binder to help keep track of medicines, insurance information, appointments, test results, and questions to ask the doctor.

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Your loved one may not recognize some side effects of their treatment, which means you may notice some side effects first. Watch out for:
  • Trouble thinking: Sluggish thought or fogginess, difficulty multitasking, issues with short-term memory or recall
  • Changes in mood: Feeling sad, anxious, or irritable
  • Mental confusion: Smelling, hearing, or seeing things that are not real
  • Speech effects: Trouble finding the right words, or slurred speech
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Your loved one may be concerned that reporting side effects may stop or interrupt their treatment. It is important to let the doctor know about side effects right away.

You may want to encourage your loved one to use the Treatment Journal to record and reflect on their experience.

Find more resources in the Downloads section.

Be mindful of your own needs

It is natural for you to want to be there for your loved one who has ALK+ mNSCLCinfo-iconALK+ mNSCLCALK+ mNSCLC stands for anaplastic lymphoma kinase–positive (ALK+) metastatic non–small cell lung cancer.. To provide the best support as a care partner, you must also care for yourself.

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Reach out to others. Talk to other people about what you are going through as a care partner. Consider reaching out to a social worker, psychologist, or community leader who can help you cope and provide guidance during this challenging time.

support group

Join a support or advocacy group. Share experiences and gain strength from others in the lung cancer community. These groups can provide important tools and useful resources. Some advocacy groups are listed above.

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Turn to Pfizer Oncology Together for financial assistance resources and personalized support.

caller icon

Call 1-877-744-5675
(Monday–Friday 8 am–8 pm ET)

Visit PfizerOncologyTogether.com

Important Safety Information

LORBRENA can cause serious side effects, including:

  • Liver problems due to interactions with other medicines. Liver problems can be severe. It is important to know what medicines not to take during treatment with LORBRENA.
  • Central nervous system (CNS) effects. CNS effects can be severe. Tell your healthcare provider if you get any new or worsening symptoms of CNS effects, including: problems with thinking, such as forgetfulness or confusion, changes in mood, such as depression and thoughts about suicide or dying, psychotic effects, such as seeing or hearing things that are not real (hallucinations), seizures, changes in speech, and changes in sleep.
  • Increases in the cholesterol and triglycerides (lipid) levels in your blood. Most people will get an increase in the lipid levels in their blood during treatment with LORBRENA.
    • If you get increases in the lipid levels in your blood, your healthcare provider may start you on a new medicine or increase your dose if you are already taking a medicine to lower the lipid levels in your blood.
    • Your healthcare provider will do blood tests to check the lipid levels in your blood before starting treatment, 1 and 2 months after starting treatment, and during treatment with LORBRENA.
  • Heart problems. LORBRENA can cause very slow or abnormal heartbeats. Your healthcare provider will check your heart rhythm (electrocardiogram or EKG) before starting and during treatment with LORBRENA. In some people, these problems are severe, and you may need to get a pacemaker. Tell your healthcare provider right away if you feel dizzy or faint or have abnormal heartbeats.
  • Lung problems. LORBRENA can cause severe or life-threatening swelling (inflammation) of the lungs during treatment that can lead to death. Symptoms may be like those from lung cancer. Tell your healthcare provider right away if you get any new or worsening symptoms of lung problems, including trouble breathing, shortness of breath, cough, or fever.
  • High blood pressure (hypertension). Your healthcare provider will check your blood pressure before starting treatment, 2 weeks after starting treatment, and then at least every month during treatment with LORBRENA. Your healthcare provider may start or change your blood pressure medicine if you get high blood pressure. Tell your healthcare provider right away if you get signs or symptoms of high blood pressure, including headaches, dizziness, blurred vision, chest pain, or shortness of breath.
  • High blood sugar (hyperglycemia). LORBRENA can cause new or worsening increases in your blood sugar levels. Your healthcare provider will do blood tests to check your blood sugar levels before starting and during treatment with LORBRENA. Your healthcare provider may start or change your blood sugar medicine if you get high blood sugar. Tell your healthcare provider right away if you get any signs and symptoms of high blood sugar, including: feeling very thirsty, needing to urinate more than usual, feeling very hungry, feeling sick to your stomach, feeling weak or tired, and feeling confused.

If you get serious side effects during treatment, your healthcare provider may change your dose, temporarily stop, or permanently stop treatment with LORBRENA.

Before taking LORBRENA, tell your healthcare provider about all of your medical conditions, including if you:

  • have kidney problems
  • have liver problems
  • have had episodes of depression or seizures
  • have high levels of cholesterol or triglycerides in your blood
  • have problems with your heartbeat
  • have lung or breathing problems
  • have high blood pressure
  • have diabetes or high blood sugar
  • are pregnant or plan to become pregnant. LORBRENA can harm your unborn baby.
  • Females who are able to become pregnant:
    • Your healthcare provider will do a pregnancy test before you start treatment with LORBRENA.
    • Tell your healthcare provider right away if you become pregnant or think you may be pregnant during treatment with LORBRENA.
    • Use effective non-hormonal birth control during treatment and for at least 6 months after the final dose of LORBRENA.
    • Birth control pills (oral contraceptives) and other hormonal forms of birth control may not be effective if used during treatment with LORBRENA. Talk to your healthcare provider about birth control choices that are right for you during this time.
  • Males with female partners who are able to become pregnant:
    • Use effective birth control during treatment and for at least 3 months after the final dose of LORBRENA.
  • are breastfeeding or plan to breastfeed. It is not known if LORBRENA passes into your breast milk. Do not breastfeed during treatment and for 7 days after the final dose of LORBRENA. Talk to your healthcare provider about the best way to feed your baby during this time.

Tell your healthcare provider about all the medicines you take, including prescription medicines, over-the-counter medicines, vitamins, and herbal supplements. Taking LORBRENA with certain other medicines may increase your risk of side effects and may affect the way LORBRENA or the other medicines work.

Know the medicines you take. Keep a list of them to show to your healthcare provider and pharmacist when you get a new medicine.

Do not take LORBRENA if you take certain other medicines called strong CYP3A inducers. Ask your healthcare provider for a list of these medicines if you are not sure.

The most common side effects of LORBRENA include:

  • swelling in your arms, legs, hands, and feet (edema)
  • numbness and tingling feeling in your joints or arms and legs (peripheral neuropathy)
  • weight gain
  • problems with thinking, such as forgetfulness or confusion
  • tiredness (fatigue)
  • difficulty breathing
  • pain in your joints
  • diarrhea
  • changes in mood, such as depression and irritability
  • increased cholesterol and triglyceride levels in the blood
  • cough

LORBRENA may cause decreased fertility in males, which may affect your ability to have children. Talk to your healthcare provider if you have concerns about fertility.

These are not all of the possible side effects of LORBRENA.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

What is LORBRENA?

Indication

LORBRENA is a prescription medicine that is used to treat adults with non-small cell lung cancer (NSCLC) that is caused by an abnormal anaplastic lymphoma kinase (ALK) gene, and that has spread to other parts of your body (metastatic).

Your healthcare provider will perform a test to make sure that LORBRENA is right for you.

It is not known if LORBRENA is safe and effective in children.

Please see Full Prescribing Information and Patient Information.

© 2026 Pfizer Inc.  All rights reserved.

The product information provided in this site is intended for residents of the United States. The products discussed herein may have different product labeling in different countries.

The health information contained herein is provided for educational purposes only and is not intended to replace discussions with a healthcare provider. All decisions regarding patient care must be made with a healthcare provider, considering the unique characteristics of the patient.

Pfizer, PO Box 29387, Mission, KS 66201.

Last Updated: April 2026  PP-LOR-USA-1068

LORBRENA ® is a registered trademark of Pfizer Inc.